Collaborative Study Sheds Light on Mechanical Stress in Bone Regeneration

Andytech, a dedicated industry-university-research practice base for multiple universities and research institutions, has achieved a significant milestone in bone regeneration research in collaboration with Southern Medical University. This joint effort has shed light on the mechanism of mechanical stress - driven bone regeneration, bringing new hope for bone - related medical treatments.

I. Productive Collaboration Yields Impressive Results

Andytech has always been enthusiastic about exploring cutting - edge technologies. Beyond providing essential hardware support such as facilities and materials, its in - house scientists actively engage in scientific research projects, participating deeply in research and paper - writing. This long - standing commitment has led to numerous achievements over the years. The co - authored paper by Southern Medical University and Andytech has now unlocked the secrets of how mechanical stress promotes bone regeneration.

II. Publication in a Prestigious Journal Validates Research Excellence

The research findings were published in the journal Cell Communication and Signaling. Renowned in the biological field, this journal focuses on cell communication and signal transduction and ranks highly in terms of impact factor among similar publications. It is dedicated to featuring innovative and influential research. The publication of this study in this journal is a testament to the outstanding value and top - notch academic quality of the collaborative research between Andytech's researchers and Southern Medical University.

III. Addressing Challenges with Innovative Approaches

During clinical bone repair, the mechanism by which mechanical stress promotes bone regeneration has remained an unsolved puzzle. To crack this mystery, the joint research teams zeroed in on integrin αVβ3 and Yes - associated protein (YAP). By adopting a multi - pathway co - inhibition strategy, combined with cyclic mechanical loading that mimics the human physiological mechanical environment, and leveraging high - precision molecular detection techniques, the researchers successfully established a 3D signal regulation network verification model. This model laid a solid foundation for further in - depth exploration of the regulatory mechanisms.

IV. Key Discoveries Unlock the Code of Bone Regeneration

The research process was filled with important findings. Cyclic tensile stress acts like a "catalyst" for bone formation, causing a 2.3 - fold increase in the expression of osteogenic markers ALP/RUNX2. However, an interesting phenomenon emerged when integrin αVβ3 was inhibited. Although YAP nuclear localization was enhanced, the osteogenic ability decreased. Additionally, when the microfilament structure was disrupted, the passage for YAP to enter the nucleus was blocked, leading to a reduction in osteogenic activity. Most significantly, the "integrin αVβ3 - microfilament - YAP" cascade signaling axis was identified for the first time, which is crucial for understanding the bone regeneration mechanism.

V. Potential for Fruitful Application

These research results are of great significance. They not only reveal the molecular and cytological mysteries of how mesenchymal stem cells respond to mechanical stress and activate transcription but also provide key theoretical support for bone regeneration therapies targeting αVβ3 integrin. Andytech's unique "EUDE FOAM™" material has promising potential. Based on these findings, the company plans to develop a series of fracture braces and supports with stress - promoting bone repair functions. These products are expected to offer new solutions for patients, potentially making the rehabilitation process more efficient and convenient.

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Full paper: https://doi.org/10.1186/s12964 - 022 - 01027